Veterinarians in the early 1950s took up phenylbutazone, which they commonly called PBZ, as enthusiastically as their medical counterparts had. They used it to treat joint afflictions, particularly in horses where its anti-inflammatory action countered lameness, the main reason that prevented a horse’s ability to work or to be ridden in sport or recreation. Phenylbutazone was relatively cheap, came in many formulations, was easy to administer and experienced to be highly effective, with minimal, if any, side effects.

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