That there were species differences in the rates at which phenylbutazone was metabolised had been known since the early 1950s (Burns et al. 1953), but this knowledge seems to have had little impact amongst veterinarians. There was no citation of the Burns et al. (1960) paper in the veterinary literature before the early 1970s (see Bogan 1972; Moss and Haywood 1973), nor any published concerns about the drug’s safety (Dalton 1956).
You Bute – Part 4
